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Microgeographic factors and patterns of aeroallergen sensitisation

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The known Socio-economic and geographic factors influence allergic sensitisation. 

The new Coastal proximity, climate, and environmental (urban v regional) factors affect allergy patterns in the Greater Sydney area. A selected ten-aeroallergen skin prick test (SPT) panel identified 98.5% of atopic patients in our sample. 72.4% of grass-sensitised patients were co-sensitised to both temperate and subtropical grasses. 

The implications The identified patterns of allergic sensitisation can inform more effective aeroallergen avoidance strategies. The high level of co-sensitisation to temperate and subtropical grasses suggests that existing immunotherapy is suboptimal in the Australian setting. Our selected Australian SPT panel may assist clinicians screening for allergy. 

Allergic sensitisation is the first step in the pathogenesis of allergic disease. Socio-economic and geographic factors, including rural environment and climate, affect patterns of allergic sensitisation.1,2 Recognising sensitisation patterns may inform more effective allergen avoidance strategies, and help guide approaches to testing for and treating allergies.…