Log in with your email address username.


Important notice

doctorportal Learning is on the move as we will be launching a new website very shortly. If you would like to sign up to dp Learning now to register for CPD learning or to use our CPD tracker, please email support@doctorportal.com.au so we can assist you. If you are already signed up to doctorportal Learning, your login will work in the new site so you can continue to enrol for learning, complete an online module, or access your CPD tracker report.

To access and/or sign up for other resources such as Jobs Board, Bookshop or InSight+, please go to www.mja.com.au, or click the relevant menu item and you will be redirected.

All other doctorportal services, such as Find A Doctor, are no longer available.

Patients left in limbo by listing stand-off

- Featured Image

The Federal Government’s top medicines advisor has lashed out at a major pharmaceutical company as a row over the subsidised supply of a life-saving but very expensive treatment for a rare illness deepened last week.

Associate Professor Suzanne Hill, who chairs the powerful Pharmaceutical Benefits Advisory Committee (PBAC), has accused drugs supplier Alexion of unnecessarily alarming people with the rare and potentially fatal disorder atypical Haemolytic Uraemic Syndrome (aHUS) over its claims about conditions laid down by her committee for the subsidised supply of the treatment Soliris.

Federal Cabinet has set aside $63 million over the next four years to subsidise access to Soliris, which has been formulated to treat aHUS – which can cause blood clots to form in small blood vessels throughout the body, potentially leading to stroke, heart attack, kidney failure and death.

About 35 people, including children, are diagnosed with the disease every year, and Soliris has been hailed as a breakthrough treatment that not only can control symptoms and the severity of attacks, but can restore critical organ function and lead to remission in some patients.

But so far, the treatment’s prohibitively high cost – more than $500,000 to treat a single patient for a year – has put it out of the reach of most sufferers.

In approving the listing of Soliris on the PBS, Cabinet followed the advice of the PBAC that although Soliris demonstrated significant clinical benefits in the short-term, there was little evidence to support its sustained use in patients who had experienced remission.

Following a meeting in late August, the PBAC recommended that Soliris be supplied through the PBS, but that therapy be discontinued for patients in remission at 12 months – subject to ongoing monitoring and an immediate resumption of treatment at any sign of a relapse.

“In reaching this conclusion the PBAC noted, among other matters, that the vast majority of the benefit observed in patients receiving [Soliris] occurs in the first six months of treatment,” the Committee said in a statement.

Health Minister Peter Dutton said the criteria set by the PBAC for commencing treatment with Soliris, its termination and possible recommencement, reflected “principles of good medical practise”.

But the drug firm Alexion, which makes Soliris, objects strongly to supplying the drug on the terms set by the Government.

Managing Director of Alexion’s Australian subsidiary, David Kwasha, told PharmaDispatch the company could not accept what it considered to be “inhumane treatment conditions”.

“It’s dangerous, clinically inappropriate, and goes against dose administration guidelines,” Mr Kwasha said. “We all agree that this needs to be resolved quickly, we have this one issue, but we just can’t agree to the experiment being proposed by the PBAC.”

He said the nature of the condition meant that, even though the PBAC criteria allowed for the reintroduction of therapy where there is a relapse, “for some patients it could be too late”.

“We remain hopeful for a change in the criteria, at least so that those patients at highest risk can continue on treatment beyond 12 months,” Mr Kwasha said.

But A/Professor Hill reacted vehemently to what she considered to be Alexion’s gross misrepresentation of the PBAC’s recommendation, which she believed had unduly alarmed patients and delayed listing of the drug.

“Let me be clear about what the PBAC recommended,” she told Medical Observer. “We have not recommended that all patients must stop receiving treatment after 12 months.”

Mr Dutton sought to put the onus for any delay in the supply of Soliris on to Alexion.

“The Government has acted upon the PBAC’s expert advice and, as a result, aHUS patients should be aware that the Government is ready to make this treatment available to them and is awaiting the response of the drug sponsor Alexion to the independent PBAC’s recommendation for the listing of Soliris,” the Minister said.

Adrian Rollins