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[Perspectives] Inflamed depression

Can inflammation cause depression? I felt off-colour for a day or so after being vaccinated against typhoid. All of us, probably, have had similar mood blips after an infection or vaccination. Anecdotally, such experiences hint that inflammation might predict depressive symptoms: the inflammatory stimulus comes before the depressive response. But in the Cartesian dualist framework of western medicine, which puts mind and body poles apart, this idea that inflammation of the body might predict depression of the mind is disruptive and demands much more than anecdotal evidence if it is to be taken seriously.

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