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[Perspectives] Understanding heartbreak: from Takotsubo to Wuthering Heights

Although an enduring subject of art, music, and literature, it was not until the 1990s that medicine concluded that one can succumb to a broken heart. Japanese physician Hikaru Sato characterised the first case reports of Takotsubo cardiomyopathy, a cardiac response to acute emotional stress. The condition was poetically dubbed the “broken heart syndrome”.