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Schizophrenia and depression

This is a republished version of an article previously published in MJA Open

Schizophrenia is a disorder characterised by positive symptoms (delusions and hallucinations), negative symptoms (apathy, withdrawal, paucity of thought and restriction of affect), disorganisation symptoms (disorganised thoughts and actions)1 and cognitive impairment (memory, attention, working memory, problem solving, processing speed and social cognition).2 Many people with schizophrenia have a limited and isolated existence, in addition to high rates of unemployment, low income and poor physical health.3 Misuse of alcohol and illicit substances is common among people with schizophrenia.4,5 All these factors contribute to high rates of depression in people with schizophrenia.

Around a quarter of people with schizophrenia meet criteria for a depressive disorder at some time in their lives.6 However, many more people with schizophrenia experience subthreshold depressive…