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Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine

To the Editor: 1,3-Dimethylamylamine (DMAA) is a substance with amphetamine-like effects found in bodybuilding and weight-loss products and recreational drugs (also marketed as methylhexaneamine, dimethylpentylamine and geranium).1 DMAA was recently banned in Australia and other countries owing to toxicity, lack of health benefits, and concerns about long-term safety and potential for misuse.2 However, published evidence for safety concerns has been remarkably limited; just a few cases report cerebral haemorrhage and cardiomyopathy.1

Many adverse effects from products containing DMAA have been reported by members of the public and health professionals to the NSW Poisons Information Centre (NSWPIC). We searched product and ingredient names obtained from a Human Performance Resource Center list3 by free-text searching on the NSWPIC database, as described previously, from 1 January 2004 to 12 October 2012.4 J A B performed the data extraction and coding, and N A B assisted where notes from telephone calls were unclear.

Over the last 3.5 years of the study period, 50 calls…